Artificial Arthropod Exoskeletons/Fungi Cell Walls Integrating Metal and Biocatalysts for Heterogeneous Synergistic Catalysis of Asymmetric Cascade Transformations

Abstract A novel and sustainable tandem‐catalysis system for asymmetric synthesis is disclosed, which fabricated by bio‐inspired self‐assembly of artificial arthropod exoskeletons (AAE s) or fungi cell walls ( AFCW containing two different types catalysts (enzyme metal nanoparticles). The heterogeneous integrated enzyme/metal nanoparticle AAE / systems, contain chitosan as the main structural component, co‐catalyze dynamic kinetic resolution primary amines via a tandem racemization/enantioselective amidation reaction process to give corresponding amides in high yields excellent ee. systems display successful synergistic catalysis at surfaces since they can catalyze multiple cycles without leaching. use natural‐based biocompatible components makes fully biodegradable renewable, thus fulfilling important green chemistry requirements.